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KMID : 0390220060170010066
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Journal of Clinical Otolaryngology, Head and Neck Surgery
2006 Volume.17 No. 1 p.66 ~ p.72
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Expression of COX-2 in Salivary Gland Tumor
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Keum Hyo-Sub
Lee Yong-Seop
Kim Kyung-Rae
Tae Kyung
Paik Seung-Sam
Park Chul-Won
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Abstract
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Objectives :Cyclooxygenase (COX) is the rate limiting enzyme in the conversion of arachidonic acid to rostaglandins. To date, two isoforms of COX, COX-1 and COX-2, have been identified. Especially, elavated COX-2 expression has been shown to occur in several malignancies. In the head and neck, COX-2 has been reported to be up-regulated in squamous cell carcinomas. The aim of this study is to evaluate the significance of expression of COX-2 in benign and malignant salivary gland tumors.Materials and Methods : Immuno-histochemical analysis was used to detect expression of COX-2 in paraffin-embedded samples from 63 benign and 51 malignant salivary gland tumors. Results were analyzed between benign and malignant tumors and co-mpared with the clinical parameters such as stage and recurrence in malignant tumors.Results：COX-2 over-expression was detected in 23.8% of the benign salivary gland tumors and 33.3% of the malignant salivary gland tumors. But there was no statistical significance. According to histologic classification in benign Sali-vary gland tumor, COX-2 overexpression of COX-2 was detected in 32.5% of pleomorphic adenoma and in 10.5% of warthin’s tumor. In malignant salivary gland tumor, COX-2 overexpression was detected in 33.3% of mucoepidermoid carcinoma. And in 26.6% of adenoid cystic carcinoma. But there were no statistical signi-ficance. 31% of male were positive for COX-2 and 25% of female were positive for COX-2. Male showed sli-ghtly higher expression rate, but there was no statistical significance.Conclusions : COX-2 overexpression is not associated with the progression of malignant salivary gland tumors. But there are many reports that COX-2 is associated with carcinogenesis in other malignant tumors. So further studies with large number of patient will be needed. (J Clinical Otolaryngol 2006;17:66-72)
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KEYWORD
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Salivary gland tumor, Cyclooxygenase-2
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